A study on piperine, active compound of black pepper

Piperine, the most important compound of black pepper, is used for treating several diseases such as breast, colon, rectal, and stomach cancer. In this study, the thermodynamical properties of this molecule in blood were obtained by using DFT and HF at the level of B3LYP/6-31+g(d,p). The results of calculations indicate that Piperine is less stable. So, ıt can react easily with radicalic forms and decrease their harmful effects and damage to the cell structures. It can dissolves in blood and reaches every tissues of the body because of the high polarity.